About this grant
The National Institutes of Neurological Disorders and Stroke (NINDS) is interested in supporting research projects proposing the optimization and translational development of genomic and biologic therapeutic candidates for Alzheimer’s Disease-Related Dementias (ADRD). Breakthroughs in genomic and biologic therapies are creating new opportunities to treat, prevent, and potentially modify the course of dementias; however, progress is limited by challenges in delivery, safety, manufacturability, and readiness for clinical testing. This program is intended to support projects across the translational pipeline, from optimization through IND development and early clinical evaluation, for genomic and biologic therapeutic candidates with compelling preclinical evidence. Eligible projects may include activities to refine therapeutic design and manufacturability; establish pharmacology, toxicology, biodistribution, and in vivo efficacy; to generate the full body of data required to support regulatory interactions and IND submissions, and, when appropriate, first-in-human (FIH) clinical studies. The program is aligned with priorities from the ADRD Summits, including acceleration of disease-modifying therapeutic development in frontotemporal degeneration (FTD), Lewy body dementia (LBD), and vascular contributions to cognitive impairment and dementia (VCID). Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Who can apply
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What it funds
How to apply
Read the full announcement on Grants.gov before you start. Federal applications are submitted through Grants.gov (or the agency's own system) and require a Unique Entity ID from SAM.gov. Registration can take several weeks, so start early. Contact: NINDS ADRD Program · nindsdonadrd@mail.nih.gov · Please contact via e-mail
What are the odds for a first-time applicant?
Mostly repeat grantees: only 4% of awards go to new applicants. Apply with a strong track record or a partner who has won before. Based on 2,734 new awards in FY2023–25. Organizations under $1M in revenue won 1% of the awards that went to nonprofits. The median award is $460,625. Expect about 168 days between posting and deadline.
Who can apply for Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)?
Eligible applicants: State governments; Private colleges & universities; Native American tribal organizations; Small businesses; County governments; City or township governments; Independent school districts; Public & Indian housing authorities; Public & state-controlled colleges; For-profit organizations; Federally recognized tribal governments; Others (see eligibility text); Special district governments; 501(c)(3) nonprofits; Nonprofits without 501(c)(3) status. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
When is the deadline?
Applications are due Nov 10, 2026. Always confirm the time and time zone in the official announcement.
Similar open grants
All health grants| Deadline | Grant | Funder | Award ceiling |
|---|---|---|---|
| Rollingno deadline | CVS Health Foundation — GrantsCorporateCVS Health Foundation | CVS Health Foundation | Not listed |
| Rollingno deadline | United Health Foundation — GrantsCorporateUnited Health Foundation | United Health Foundation | Not listed |
| Rollingno deadline | The California Endowment — GrantsFoundationThe California Endowment | The California Endowment | Not listed |
| Rollingno deadline | The Commonwealth Fund — GrantsFoundationThe Commonwealth Fund | The Commonwealth Fund | Not listed |
| Rollingno deadline | The Duke Endowment — GrantsFoundationThe Duke Endowment | The Duke Endowment | Not listed |
| Rollingno deadline | Bill & Melinda Gates Foundation — Grant OpportunitiesFoundationBill & Melinda Gates Foundation | Bill & Melinda Gates Foundation | Not listed |