About this grant
The National Institutes of Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose feasibility studies that could inform the design and conduct of subsequent definitive clinical trials (e.g., efficacy, effectiveness, pragmatic, dissemination and implementation, phase/stage II or later trials). Applications to this NOFO should demonstrate that the proposed feasibility research is scientifically necessary to design or plan the subsequent definitive clinical trial. Studies may utilize mixed methods and feasibility clinical trials to assess feasibility of recruitment, randomization, retention, intervention delivery, data collection, adherence, acceptability, and/or develop or adapt intervention components or protocols. The proposed feasibility research should enhance the rigor and reproducibility of the future trial methods. The subsequent definitive clinical trial should have the potential to make a significant impact on public health. Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise in clinical trial planning, design, implementation, intervention development, and/or stakeholder engagement are encouraged to begin to consider applying for this new NOFO.
Who can apply
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What it funds
How to apply
Read the full announcement on Grants.gov before you start. Federal applications are submitted through Grants.gov (or the agency's own system) and require a Unique Entity ID from SAM.gov. Registration can take several weeks, so start early. Contact: NCCIH Division of Extramural Research Program Officer · NCCIHDERFunding@nih.gov · Please contact via e-mail
What are the odds for a first-time applicant?
A realistic target for an established nonprofit. 21% of awards go to first-time applicants and nonprofits win 19%. Based on 211 new awards in FY2023–25. The median award is $491,398. Expect about 173 days between posting and deadline.
Who can apply for Feasibility Studies to Inform the Design of Future Clinical Trials?
Eligible applicants: Small businesses; Independent school districts; Private colleges & universities; City or township governments; Native American tribal organizations; State governments; Public & state-controlled colleges; Special district governments; Nonprofits without 501(c)(3) status; Others (see eligibility text); County governments; Public & Indian housing authorities; 501(c)(3) nonprofits; For-profit organizations; Federally recognized tribal governments. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
When is the deadline?
Applications are due Feb 16, 2027. Always confirm the time and time zone in the official announcement.
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