National Biomedical Research Centers (P50 Clinical Trial Optional)

The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Read the full announcement on Grants.gov before you start. Federal applications are submitted through Grants.gov (or the agency's own system) and require a Unique Entity ID from SAM.gov. Registration can take several weeks, so start early. Contact: Division of Comparative Medicine, Office of Research Infrastructure Programs · ORIPDCM@mail.nih.gov · 301-451-2074