About this grant
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the continued support of the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. The goal of the CTOT-CA is to improve the outcome of organ transplantation through clinical trials with mechanistic studies. The CTOT-CA will support multicenter clinical trials, with associated studies of immune mechanisms, in heart, lung, kidney, liver, and intestinal transplantation. The program will also support clinical trials of non-hematopoietic cellular transplantation as replacement therapies; vascularized composite tissue transplantation; and transplantation of bone marrow or mesenchymal stem cells, or of immunologically active cells, as adjuncts to organ transplantation. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What it funds
How to apply
Read the full announcement on Grants.gov before you start. Federal applications are submitted through Grants.gov (or the agency's own system) and require a Unique Entity ID from SAM.gov. Registration can take several weeks, so start early. Contact: DAIT Transplantation Branch Clinical Trial Leadership · CTOT_CA_U01@mail.nih.gov · Please contact via email.
What are the odds for a first-time applicant?
Mostly repeat grantees: only 4% of awards go to new applicants. Apply with a strong track record or a partner who has won before. Based on 4,772 new awards in FY2023–25. Organizations under $1M in revenue won 1% of the awards that went to nonprofits. The median award is $445,500. Expect about 133 days between posting and deadline.
Who can apply for Clinical Trials in Organ Transplantation in Children and Adults?
Eligible applicants: City or township governments; Native American tribal organizations; Small businesses; Independent school districts; Special district governments; Federally recognized tribal governments; State governments; Others (see eligibility text); Private colleges & universities; For-profit organizations; Public & state-controlled colleges; Public & Indian housing authorities; Nonprofits without 501(c)(3) status; County governments; 501(c)(3) nonprofits. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
When is the deadline?
Applications are due Sep 30, 2027. Always confirm the time and time zone in the official announcement.
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