About this grant
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance the National Institutes of Health (NIH) mission by utilizing Special Statutory Funding Program for Type 1 Diabetes Research funds to support studies focused on the involvement of the innate immune system in the initiation of Type 1 diabetes (T1D). This initiative directly aligns with the first goal of the congressionally mandated Special Diabetes Program, which is to identify the genetic and environmental causes of T1D. By engaging multidisciplinary teams with expertise in innate immunity and beta-cell biology, the program aims to elucidate how innate immune components interact with pancreatic tissues and beta cells. The program will leverage the use of new approach methodologies (NAMs) to precisely define the timing and impact of environmental perturbations that activate innate immune pathways. Ultimately, these studies may enable earlier identification of individuals at elevated risk for T1D (beyond genetic susceptibility) and lay the groundwork for future prevention and therapeutic strategies. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Who can apply
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What it funds
How to apply
Read the full announcement on Grants.gov before you start. Federal applications are submitted through Grants.gov (or the agency's own system) and require a Unique Entity ID from SAM.gov. Registration can take several weeks, so start early. Contact: RISP-T1D · NIAID_DAIT_T1D@mail.nih.gov · Please contact via e-mail
What are the odds for a first-time applicant?
Mostly repeat grantees: only 4% of awards go to new applicants. Apply with a strong track record or a partner who has won before. Based on 4,772 new awards in FY2023–25. Organizations under $1M in revenue won 1% of the awards that went to nonprofits. The median award is $445,500. Expect about 133 days between posting and deadline.
Who can apply for The Role of the Innate Immune System in the Pathogenesis of Type 1 Diabetes?
Eligible applicants: Nonprofits without 501(c)(3) status; For-profit organizations; Special district governments; Public & state-controlled colleges; Public & Indian housing authorities; State governments; Small businesses; County governments; Independent school districts; Others (see eligibility text); Federally recognized tribal governments; Private colleges & universities; Native American tribal organizations; City or township governments; 501(c)(3) nonprofits. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
When is the deadline?
Applications are due Oct 13, 2027. Always confirm the time and time zone in the official announcement.
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